ホーム » People » Faculty/Researchers » 谷口 善仁 （専任講師）
谷口 善仁 Yoshihito TaniguchiTitle専任講師 Research Areas/Key Words環境分子医学、生体分子応答学宇宙医学、放射線医学 環境中毒学、トキシコロジー | |
Background慶應義塾大学医学部 1992年卒Teaching衛生学、放射線基礎医学、分子生物学Research遺伝子改変メダカの作製と環境評価詳細は上記参照 Selected PublicationsDual Functions of ASCIZ in the DNA Base Damage Response and Pulmonary Organogenesis. Jurado S, Smyth I, van Denderen B, Tenis N, Hammet A, Hewitt K, Ng JL, McNees CJ, Kozlov SV, Oka H, Kobayashi M, Conlan LA, Cole TJ, Yamamoto K, Taniguchi Y, Takeda S, Lavin MF, Heierhorst J PLoS Genetics 2010 in pressRAP80 Acts Independently of BRCA1 in Repair of Topoisomerase II Poison-Induced DNA Damage. Iijima J, Zeng Z, Takeda S, Taniguchi Y. Cancer Res. 2010 in press Proteasome inhibition in medaka brain induces the features of Parkinson's disease. Matsui H, Ito H, Taniguchi Y, Inoue H, Takeda S, Takahashi R. J Neurochem. 2010 Oct;115(1):178-87. Nakamura K, Kogame T, Oshiumi H, Shinohara A, Sumitomo Y, Agama K, Pommier Y, Tsutsui KM, Tsutsui K, Hartsuiker E, Ogi T, Takeda S, Taniguchi Y. Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair. PLoS Genet. 6:e1000828, 2010. Matsui H, Taniguchi Y, Inoue H, Kobayashi Y, Sakaki Y, Toyoda A, Uemura K, Kobayashi D, Takeda S, Takahashi R. Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement. Neurosci Res. 66:151-161, 2010. メダカのパーキンソン病モデル。 Schartl M, Wilde B, Laisney JA, Taniguchi Y, Takeda S, Meierjohann S. A mutated EGFR is sufficient to induce malignant melanoma with genetic background-dependent histopathologies. J Invest Dermatol. 130:249-258, 2010. メダカのメラノーマモデル。 Ji K, Kogame T, Choi K, Wang X, Lee J, Taniguchi Y, Takeda S. A novel approach using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants. Environ Health Perspect. 117:1737-1744 2009. 化学物質のDNA障害性の迅速アッセイ。 Kawasaki T, Saito K, Mitsui K, Ikawa M, Yamashita M, Taniguchi Y, Takeda S, Mitani K, Sakai N. Introduction of a foreign gene into zebrafish and medaka cells using adenoviral vectors. Zebrafish. 6:253-258, 2009. メダカ培養細胞への遺伝子導入法。 Matsui H, Taniguchi Y, Inoue H, Uemura K, Takeda S, Takahashi R. A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish. Neurosci Res. 65:263-71, 2009. 薬剤を用いたメダカのパーキンソン病モデル。 Kikuchi K, Abdel-Aziz HI, Taniguchi Y, Yamazoe M, Takeda S, Hirota K. Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences. J Biol Chem. 284:26360-26367, 2009. 体細胞におけるブルームヘリカーゼの役割。 Nakahara M, Sonoda E, Nojima K, Sale JE, Takenaka K, Kikuchi K, Taniguchi Y, Nakamura K, Sumitomo Y, Bree RT, Lowndes NF, Takeda S. Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes. PLoS Genet. 5:e1000356, 2009. Oka H, Sakai W, Sonoda E, Nakamura J, Asagoshi K, Wilson SH, Kobayashi M, Yamamoto K, Heierhorst J, Takeda S, Taniguchi Y. DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion. Biochem Biophys Res Commun. 371:225-229, 2008. Takeda S, Nakamura K, Taniguchi Y, Paull TT. Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. 28:351-352, 2007. Saberi A, Hochegger H, Szuts D, Lan L, Yasui A, Sale JE, Taniguchi Y, Murakawa Y, Zeng W, Yokomori K, Helleday T, Teraoka H, Arakawa H, Buerstedde JM, Takeda S. RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Mol Cell Biol. 27:2562-2571, 2007. Taniguchi Y, Takeda S, Furutani-Seiki M, Kamei Y, Todo T, Sasado T, Deguchi T, Kondoh H, Mudde J, Yamazoe M, Hidaka M, Mitani H, Toyoda A, Sakaki Y, Plasterk RH, Cuppen E.. Generation of medaka gene knockout models by target-selected mutagenesis. Genome Biol. 7:R116, 2006. 遺伝子破壊メダカの作成法。p53遺伝子破壊メダカの表現型解析。 Sonoda E, Hochegger H, Saberi A, Taniguchi Y, Takeda S. Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst). 5:1021-1029, 2006. Nakamura K, Sakai W, Kawamoto T, Bree RT, Lowndes NF, Takeda S, Taniguchi Y. Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks. DNA Repair (Amst). 5:741-749, 2006. Kikuchi K, Taniguchi Y, Hatanaka A, Sonoda E, Hochegger H, Adachi N, Matsuzaki Y, Koyama H, van Gent DC, Jasin M, Takeda S. Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends. Mol Cell Biol. 25:6948-6955, 2005. | |